Eric Kool received his Ph.D. in Chemistry from Columbia University and did postdoctoral work in nucleic acids chemistry at Caltech. He started his career at the University of Rochester before moving to Stanford in 1999, where he is the George and Hilda Daubert Professor of Chemistry. He teaches Organic Chemistry and Chemical Biology to undergraduate and graduate students.
The Kool lab uses the tools of chemistry to study the structures, interactions and biological activities of nucleic acids and the enzymes that process them. Molecular design and synthesis play a major role in this work, followed by analysis of structure and function, both in test tubes and in living systems. These studies are aimed at gaining a better basic understanding of biology, and applying this knowledge to practical applications in biomedicine.
Recent research interests include the development of chemical tools for mapping RNA structure and interactions in cells, methods for stabilization and conjugation of RNAs, and the development of probes of DNA repair pathways and their connections to cancer.
Winnacker, M., & Kool, E. T. (2013). Artificial Genetic Sets Composed of Size-Expanded Base Pairs. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(48), 12498–508.
Zhu, R.-Y. Y., Majumdar, C., Khuu, C., De Rosa, M., Opresko, P. L., David, S. S., & Kool, E. T. (2020). Designer Fluorescent Adenines Enable Real-Time Monitoring of MUTYH Activity. ACS Central Science, 6(10), 1735–42.
Singh, V., Wang, S., & Kool, E. T. (2013). Genetically encoded multispectral labeling of proteins with polyfluorophores on a DNA backbone. Journal of the American Chemical Society, 135(16), 6184–91.
Edwards, S. K., Ono, T., Wang, S., Jiang, W., Franzini, R. M., Jung, J. W., … Kool, E. T. (2015). In Vitro Fluorogenic Real-Time Assay of the Repair of Oxidative DNA Damage. CHEMBIOCHEM, 16(11), 1637–46.
Yuen, L. H., Franzini, R. M., Tan, S. S., & Kool, E. T. (2014). Large-Scale Detection of Metals with a Small Set of Fluorescent DNA-Like Chemosensors. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(41), 14576–82.
Larsen, D., Pittelkow, M., Karmakar, S., & Kool, E. T. (2015). New Organocatalyst Scaffolds with High Activity in Promoting Hydrazone and Oxime Formation at Neutral pH. Organic Letters, 17(2), 274–77.
Karmakar, S., Harcourt, E. M., Hewings, D. S., Lovejoy, A. F., Kurtz, D. M., Ehrenschwender, T., … Kool, E. T. (2015). Organocatalytic removal of formaldehyde adducts from RNA and DNA bases. NATURE CHEMISTRY, 7(9), 752–58.
Spitale, R. C., Crisalli, P., Flynn, R. A., Torre, E. A., Kool, E. T., & Chang, H. Y. (2013). RNA SHAPE analysis in living cells. Nature Chemical Biology, 9(1), 18–20.
Xiao, L., Habibian, M., & Kool, E. T. (2020). Site-Selective RNA Functionalization via DNA-Induced Structure. Journal of the American Chemical Society, 142(38), 16357–63.
Qin, S., Lin, P., Wu, Q., Pu, Q., Zhou, C., Wang, B., … Wu, M. (2020). Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection. Journal of Immunology (Baltimore, Md. : 1950).