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Eric Kool

Eric Kool

The George A. and Hilda M. Daubert Professor in Chemistry
Chemistry of RNA and DNA; probe design and imaging; synthetic biology

About

Eric Kool received his Ph.D. in Chemistry from Columbia University and did postdoctoral work in nucleic acids chemistry at Caltech. He started his career at the University of Rochester before moving to Stanford in 1999, where he is the George and Hilda Daubert Professor of Chemistry. He teaches Organic Chemistry and Chemical Biology to undergraduate and graduate students.

The Kool lab uses the tools of chemistry to study the structures, interactions and biological activities of nucleic acids and the enzymes that process them. Molecular design and synthesis play a major role in this work, followed by analysis of structure and function, both in test tubes and in living systems. These studies are aimed at gaining a better basic understanding of biology, and applying this knowledge to practical applications in biomedicine.

As part of this research, members of the group synthesize designer nucleobases and nucleotides, with unusual properties such as fluorescence, enzyme reactivity, or altered shape and H-bonding ability. We use these as tools to study DNA polymerase enzymes, DNA repair pathways, and RNA modifying enzymes. This work is leading to new probes for diagnosis of cancer, useful fluorescent tags for biology, and fluorescent sensors of many species such as cancer metabolites and toxic metals.

Appointments

Professor, Chemistry
Member, Bio-X
Member, Child Health Research Institute
Faculty Fellow, Stanford ChEM-H

Honors & Awards

Breslow Award for Achievement in Biomimetic Chemistry, American Chemical Society (2015)
O. K. Rice Lectureship, University of North Carolina (2015)
Dean’s Award for Distinguished Teaching, Stanford University (2014)
Frontiers in Chemistry Distinguished Lecturer, Case Western Reserve University (2014)
Tarrant Distinguished Lectureship, University of Florida (2014)
O’Malley Lectureship, Boston College (2012)
Tortellotte Lectureship, Kalamazoo College (2010)
Hirschmann Lectureship, Oberlin College (2003)
Novartis Lecturer, Massachusetts Institute of Technology (2003)
Fellow of the AAAS, American Association for the Advancement of Science (2002)

Professional Education

PhD, Columbia University, Organic Chemistry, Biochemistry (1988)

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