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Eric Kool

Eric Kool

George A. and Hilda M. Daubert Professor of Chemistry
Chemistry of RNA and DNA; transcriptomics; DNA repair; fluorescent probes

About

Eric Kool received his Ph.D. in Chemistry from Columbia University and did postdoctoral work in nucleic acids chemistry at Caltech. He started his career at the University of Rochester before moving to Stanford in 1999, where he is the George and Hilda Daubert Professor of Chemistry. He teaches Organic Chemistry and Chemical Biology to undergraduate and graduate students.

The Kool lab uses the tools of chemistry to study the structures, interactions and biological activities of nucleic acids and the enzymes that process them. Molecular design and synthesis play a major role in this work, followed by analysis of structure and function, both in test tubes and in living systems. These studies are aimed at gaining a better basic understanding of biology, and applying this knowledge to practical applications in biomedicine.

Recent research interests include the development of chemical tools for mapping RNA structure and interactions in cells, methods for stabilization and conjugation of RNAs, and the development of probes of DNA repair pathways and their connections to cancer.

Appointments

Professor, Chemistry
Member, Bio-X
Member, Maternal & Child Health Research Institute (MCHRI)
Faculty Fellow, Sarafan ChEM-H
Member, Stanford Cancer Institute
Member, Wu Tsai Neurosciences Institute

Honors & Awards

Murray Goodman Memorial Prize in Biopolymer Research, American Chemical Society (2021)
Breslow Award for Achievement in Biomimetic Chemistry, American Chemical Society (2015)
O. K. Rice Lectureship, University of North Carolina (2015)
Dean’s Award for Distinguished Teaching, Stanford University (2014)
Frontiers in Chemistry Distinguished Lecturer, Case Western Reserve University (2014)
Tarrant Distinguished Lectureship, University of Florida (2014)
O’Malley Lectureship, Boston College (2012)
Tortellotte Lectureship, Kalamazoo College (2010)
Hirschmann Lectureship, Oberlin College (2003)
Novartis Lecturer, Massachusetts Institute of Technology (2003)

Professional Education

PhD, Columbia University, Organic Chemistry, Biochemistry (1988)

Featured Publications