Staff Research Associate (SRA)/Specialist
We are recruiting a Staff Research Associate (SRA)/Specialist to assist with ongoing multidisciplinary CAR T cell projects. Our lab is interested in engineering next generation CAR T cell using the CRISPR/Cas9 system to enhance their activity, specificity, persistence and ultimately improve their therapeutic activity against solid tumor. We recently showed (Eyquem et al. Nature 2017) that targeting the CAR transgene to a specific locus offers optimal CAR expression that prevents undesirable differentiation and exhaustion, which results in superior anti-tumor activity in hematological malignancies. These results greatly improved the understanding of CAR biology by establishing the first link between CAR expression and anti-tumor function. We are now applying these technologies to tackle solid tumors.
Working as part of a multidisciplinary group, the SRA will utilize various protocols to generate the molecular components, such as DNA constructs, necessary for specific cellular engineering experiments. Additional responsibilities will consist of isolation and culture of primary human T cells, as well as functional analysis of engineered cells via Sanger sequencing, next-generation DNA sequencing, and flow cytometry. Strong organizational and communication skills are required. For exceptionally skilled applicants, opportunity exists to extend the SRA’s role to include the design and completion of cellular editing experiments, as well as in vivo analysis of novel cellular cancer immunotherapies. This position represents an excellent opportunity to gain exposure to basic laboratory skills as well as genetics and genome engineering skills in a dynamic, well-established research environment.
- BA/BS degree and with laboratory experience utilizing techniques or methods required by the position; or an equivalent combination of education and experience.
- Experience with general laboratory techniques, especially basic molecular and cellular biology techniques (including but not limited to DNA and RNA isolation, PCR, gel electrophoresis, DNA assembly, bacterial transformation, mammalian cell culture, etc.)
- Excellent organizational and interpersonal communication skills (verbal and written)
- Willingness and ability to learn new methods and skills for changing research priorities
- Ability to work independently and as a member of a research team
- Ability to prioritize tasks, coordinate work tasks with others, and meet multiple deadlines
- Prior experience with DNA sequencing technologies, including Sanger and NGS
- Prior experience in the design and assembly of DNA constructs (via restriction digestion and ligation, Gibson assemblies, Golden-Gate assemblies, etc.)
- Prior hands on experience with mouse handling and injections
Payment is according to the UCSF pay scale. UCSF is an equal opportunity/affirmative action employer. All qualified candidates are encouraged to apply. Please submit your complete application documents including CV and references to: email@example.com
Intern at Gilead
We are seeking an intern to investigate the use of organic solvent nanofiltration (OSN) as a tool to enable scalable separations and purifications for APIs and API intermediates. Specific Responsibilities & Desired Outcomes: - Investigate the use of organic solvent nanofiltration (OSN) as a tool to perform separations and purifications on relevant APIs or API intermediates with a specific goal of developing scalable and economical processes. - Thoroughly document laboratory experiments. - Tabulate, summarize, and present results at team meetings. - Present a summary of project work to the department at the conclusion of the internship. Candidate Experience, Knowledge, and Area of Study: - The ideal candidate is pursuing a BS/BA in chemistry or a related discipline with a specific interest in pharmaceutical or organic chemistry. Required experience and skills: A minimum of two semesters of organic chemistry coursework with labs Desired attributes: - Minimum six months of laboratory-based organic synthesis experience - Familiarity and experience with NMR, HPLC, GC, and/or other related analytical techniques - Strong interest in pharmaceutical applications of organic chemistry and process engineering.
Please apply on company website.
Tour Guide- SLAC (Casual-Nonexempt)
SLAC Job Posting
The Office of Communications seeks to communicate the vitality and breadth of science at the laboratory. Working closely with SLAC staff, the Office drives SLAC's internal and external communication efforts and promotes the laboratory's mission through effective and imaginative communications to a wide range of audiences including the general public, press and media, educators, congressional representatives, funding agencies and members of the local community.
We are seeking a highly motivated Tour Guide to join our Public Tour Program. As a SLAC Tour Guide, you will support the laboratory's tour program and lead an interesting interactive tour program that advances SLAC’s outreach activities to diverse audiences.
Your specific responsibilities include:
- Deliver an introductory overview of SLAC’s mission, history, science and accomplishments using visual aids such as animations and multimedia, PowerPoint presentations and other exhibits.
- Provide a physical tour of SLAC’s publically-accessible visitor areas explaining the scientific developments and activities as they relate to that area.
- Provide quality customer service with tour check-in, audience engagement,
- Ensure tours do not negatively impact ongoing work at SLAC—use good judgment if encountering unexpected circumstances.
- Manage the tour paperwork and follow administrative processes such as badging, key access etc, when necessary
- Support SLAC Tours SLAC Outreach Program Officer as required.
- May be required to operate a vehicle on site.
Note: This is a non-benefits eligible casual-nonexempt position (work less than 50% full-time equivalent), not to exceed 980 hours in a calendar year. Work on-call (maximum of eight hours per week)
To be successful in this position you will bring:
- Bachelor’s degree in science physics, applied physics, chemistry, biology, computer science or related fields or equivalent work experience (advanced degree preferred). Experience or involvement in science outreach, science teaching or other public facing activities or active engagement in scientific research a plus .
- Strong interest in and enthusiasm for SLAC, its history, technology and scientific work and achievements.
- Ability to engage and discuss with students and the general public.
- In-depth knowledge of at least one area of SLAC's science and/or technology.
- Ability to explain basic physics principles as they relate to SLAC's technology, machinery and activities to non-technical audiences.
- Ability to deliver an organized, clear and informative lecture or presentation to both technical and non-technical audiences.
- Ability to vary the content and delivery of information to successfully communicate to different age groups and levels of expertise.
- Good judgment and a sense of humor.
- Responsible for scheduling and commitments.
- Ability to handle questions and interruptions and respond with tact and pleasantly.
Please apply here (Job ID 3977):
Adjunct Assistant Professor in Biochemistry
Adjunct Assistant Professor in Biochemistry (up to 1.0 FTE for Winter/Spring 2020) commencing as early as January 2, 2020. This individual would be responsible for teaching biochemistry lecture and laboratory courses and may also have the opportunity to teach general and/or organic chemistry labs, as well as oversee student research.
To apply, please email:
Hala G. Schepmann, Ph.D.
Chair, Department of Chemistry
Southern Oregon University
Postdoctoral Research Scientist-RNA Therapeutics-FDE
The Lilly RNA Therapeutics Team is seeking a hardworking postdoctoral scientist to join our growing, fast-paced, interdisciplinary team as we leverage novel RNA/oligonucleotide based therapeutic modalities to enhance the Lilly portfolio. A postdoctoral research position exists within the RNA Therapeutics Group for an innovative researcher in the field of chemical biology. You will be responsible for methods to assess intracellular trafficking of RNA molecules which is expected to contribute to our understanding of RNAi as a platform to treat disease.
Primarily, you will develop and execute protocols for the quantitative analysis of subcellular distribution and confocal imaging of RNA molecules. The experiments will encompass a combination of conjugation chemistry, protein engineering, protein labeling, cellular imaging and RNA trafficking methods. It is anticipated that the research undertaken will yield novel methods and new information that would be suited for publication in high impact scientific journals.
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. #WeAreLilly
- Ph.D. in the area of cell/molecular biology, biochemistry and related areas
- Prior practical experience with cell biology and cell imaging
- Possess a solid understanding of RNA, bioconjugation strategies, and protein engineering
- Demonstrated track record for publication or presentation of research results
- This position is not permanent. It is for a fixed duration for up to 4 years
- Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
To apply: Lilly.com career page Keyword 53480