Monroe E. Spaght Professor in Chemistry and Professor of S.L.A.C. Photon Science (b. 1946)
B.S., 1968, Rensselaer; M.A., 1970; Ph.D., 1972, Princeton University

Alfred P. Sloan Foundation Fellow, 1976-79; Dupont and General Electric Young Faculty Awards, 1979-80; McElvain (1983), World Bank (1984), O. K. Rice (1984), Reilly (1986), Frontiers (1990), 1st Seaborg (1990), Frontiers in Chemistry (1991), ACS (1992), National Science Council (1993), Xerox (1994), Leermakers (1994), Amoco (1995), Kahn (1996), Golden Jubilee (1996), Karcher (1997), FMC (1998), Colloquium 3eme Cycle (1998), A.D. Little (1998); Aldrich (2001), Hill Memorial (2003), Cady (2003), Kieler Woche (2003), Crawford (2004), Walton (2005), Endicott/Rorabacker Frontier (2006), Dawson (2007), Frontiers (2007), Proctor and Gamble (2008), Andreas Albrecht (2009), Hans B. Jonassen (2009), Harteck (2009), Sunney Chan (2009) Faraday (2010), Vaughan (2011), Hans Freeman (2012), Ross (2013) Lectures; JSPS Fellow (1995, 2002, 2009); NIH Merit Award (1995 & 2002); Remsen Award (1994); Wheland Medal (2000); ACS Award in Inorganic Chemistry (2001); Frontiers in Biological Chemistry Award (MPI-2001); Centenary Medal and Lectureship (Royal Society, UK 2003); ACS Award for Distinguished Service in the Advancement of Inorganic Chemistry (2006); Bailar Medal (2007); Thomas Chemistry Scholar (2007); Chakravorty Award & Lecturer (2008); Dean's Award for Distinguished Teaching; American Association for the Advancement of Science Fellow; American Chemical Society Fellow; American Academy of Arts and Sciences Fellow; Elected to the National Academy of Sciences; Associate Editor, Inorganic Chemistry; Editorial Advisory Board Member for 14 journals.

Chemistry Research Area: 
Chemistry Research Area: 
Chemistry Research Area: 
Chemistry Research Area: 
Chemistry Research Area: 
Chemistry Research Area: 

Principal Research Interests

The fields of Inorganic, Physical, Biophysical, Bioinorganic and Theoretical-Inorganic Chemistry emphasizing the application of a wide variety of spectroscopic and computational methods to determine the electronic structure of transition metal complexes. Research is directed toward both high symmetry model complexes to define in detail electronic structure contributions to chemical and physical properties, and metal ion active sites in catalysis to understand their unusual spectral features in terms of electronic and geometric structure and to evaluate these structural contributions to reactivity. The focus of many studies is on fundamental problems in Bioinorganic Chemistry and heterogeneous and homogeneous catalysis. Areas of present interest include: 1) Electronic structure contributions to electron transfer in blue copper, CuA, iron sulfur and cytochrome c active sites; 2) O2 and N2O activation by Cu cluster active sites; 3) Structure/function correlations over non-heme iron enzymes; 4) Development of new spectroscopic and electronic structure methods in bioinorganic and physical–inorganic chemistry; 5) New spectroscopic methods using synchrotron radiation; 6) correlation of heterolytic catalytic sites in zeolites to metalloenzyme catalysis. Research emphasis is fundamental but highly relevant to energy, environment and health. 

Representative Publications

1) ”Spectroscopic Elucidation of a New Structure Type in Heme/Cu Dioxygen Chemistry: Implications for O—O Bond Rupture in Cytochrome c Oxidase,” M.T. Kieber-Emmons, M.F. Qayyum, Y. Li, Z. Halime, K.O. Hodgson, B. Hedman, K.D. Karlin, and E.I. Solomon, Angew. Chem. Int. Ed., 124, 172 (2011)

2) ”S K-edge XAS and DFT Calculations on SAM Dependent Pyruvate-Lyase Activating Enzyme: Nature of Interaction Between the Fe4S4 Cluster and SAM and it Role in Reactivity,” A. Dey, Y. Peng, W.E. Broderick, B. Hedman, K.O. Hodgson, J.B. Broderick, and E.I. Solomon, J. Amer. Chem. Soc., 133, 18656 (2011)

3) ”X-ray Absorption Spectroscopic and Computational Investigation of a Possible S…S Interaction in the [Cu3S2]3+ Core,” R. Sarangi, L. Yang, S.G. Winikoff, L. Gagliardi, C.J. Cramer, W.B. Tolman, and E.I. Solomon, J. Amer. Chem. Soc., 133, 17,180 (2011)

4) ”Nuclear Resonance Vibrational Spectroscopy on the FeIV=O S = 2 Non-Heme Site in TMG3tren: Experimentally Calibrated Insights into Reactivity,” S.D. Wong, C.B. Bell, III, L.V. Liu, Y. Kwak, J. England, E. Alp, J. Zhao, L. Que, Jr., and E.I. Solomon, Angew. Chem. Int. Ed., 50, 3215 (2011)

5) ”Activation of α-keto Acid Dependent Dioxygenases: Application of an {FeNO}7/{FeO2}8 Methodology for Characterizing the Initial Steps of O2 Activation,” A.R. Diebold, C.D. Brown-Marshall, M.L. Neidig, J.M. Brownlee, G.R. Moran, and E.I. Solomon, J. Am. Chem. Soc., 133, 18148 (2011)

6) ”Spectroscopic and Computational Studies of α-keto Acid Binding to Dke1: Understanding the role of the facial triad and the reactivity of ß-diketones,” A.R. Diebold, G.D. Straganz, and E.I. Solomon, J. Amer. Chem. Soc., 133, 15979 (2011)

7) ”Copper Dioxygen (Bio)Inorganic Chemistry,” E.I. Solomon, J.W. Ginsbach, D.E. Heppner, M.T. Kieber-Emmons, C.H. Kjaergaard, P.J. Smeets, L. Tian, and J.S. Woertink, Faraday Disc., 148, 11 (2011)

8) ”Recent Advances in Understanding Blue Copper Proteins,” E.I. Solomon and R.G. Hadt, Coord. Chem. Rev., 255, 774 (2011)

9) ”Oxygen precursor to the active intermediate in methanol synthesis by Cu-ZSM-5,” P.J. Smeets, R.G. Hadt, J.S. Woertink, P. Vanelderen, R.A. Shoonheydt, B.F. Sels, and E.I. Solomon, J. Amer. Chem. Soc., 132, 14, 736 (2010)

10) ”Defining the intermediates and mechanism of the anti-cancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods,” L.V. Liu, C.B. Bell, III, S.D. Wong, S.A. Wilson, Y. Kwak, M.S. Chow, J. Zhao, K.O. Hodgson, B. Hedman, and E.I. Solomon, Proc. Natl. Acad. Sci. U.S.A., 107, 22419 (2010)

11) "Sulfur K-edge X-ray Absorption Spectroscopy and Density Functional Calculations on Mo(IV) and Mo(VI)=O Bis-dithiolenes: Insights into the Mechanism of Oxo Transfer in DMSO Reductase and Related Functional Analogues," A.L. Tenderholt, J-J. Wang, R.K. Szilagyi, R.H. Holm, K.O. Hodgson, B. Hedman, and E.I. Solomon, J. Amer. Chem. Soc., 132, 8359 (2010)

12) ”Solvation effects on S K-edge XAS spectra of Fe-S proteins: normal and inverse effects on WT and mutant Rubredoxin,” N. Sun, A. Dey, Z. Xiao, A. Wedd, K.O. Hodgson, B. Hedman, and E.I. Solomon, J. Amer. Chem. Soc., 132, 12639 (2010)

13) "Fe L-edge X-ray Absorption Spectroscopy Determination of Differential Orbital Covalency of Siderophore Model Compounds: Electronic Structure Contributions to High Stability Constants," R. Hocking, S. Debeer George, K. Raymond, K.O. Hodgson, B. Hedman, and E.I. Solomon, J. Am. Chem. Soc., 132, 4006 (2010)

14) "Systematic Perturbation of the Trinuclear Copper Cluster in the Multicopper Oxidases: The Role of Active Site Asymmetry in its Reduction of O2 to H2O," A.J. Augustine, C. Kjaergaard, M. Qayyum, L. Ziegler, D. Kosman, K.O. Hodgson, B. Hedman, and E.I. Solomon, J. Am. Chem. Soc., 132, 6057 (2010)