Professor Bryan Roth, University of North Carolina at Chapel Hill
S.G. Mudd Building
Stanford University
“Drugging the Subterranean GPCR-ome”
About the Seminar
G-protein coupled receptors represent the largest family of druggable targets in the human genome, yet for most of them both their structure and function is unknown. From a chemistry perspective most are subterranean in the sense that we have no chemical probes with which to modulate their activity. Over the past several years my lab has been attempting to clarify the 'hidden' or unknown pharmacology and actions of known drugs and chemical probes (Keiser et al, Nature 2009; Besnard et al, Nature 2012; Wacker et al, Science 2013; Fenalti et al, Nature 2014; Kroeze et al, accepted). In this talk I will describe novel and as yet published chemical biological approaches for elucidating the structure and function of the subterranean GPCR-ome. I will show how results from these approaches illuminate novel biology and chemistry from a GPCR-centric perspective.
About the Speaker
Bryan Roth MD, PhD is the Michael Hooker Distinguished Professor of Pharmacologyand in the Division of Chemical Biology and Medicinal Chemistry at UNC Chapel Hill Medical School. Bryan was born and raised in the Northwest (Montana), spent time in graduate and medical school in the Midwest, did postdoctoral training on the East Coast and ultimately trained in Psychiatry and molecular biology on the West Coast at Stanford. He now resides in the Southeast (North Carolina). He is a member of the Institute of Medicine of the National Academy of Sciences.
This Student Hosted Colloquium is hosted by:
