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Organic Chemistry Seminar: Dr. Alison Wendlandt, Harvard University

Alison Wendlandt
January 16, 2018 - 4:30pm
Sapp Center Lecture Hall

Organic Chemistry Seminar: Dr. Alison Wendlandt, Harvard University (Host: Justin Du Bois)

"Mechanism-guided development of selective catalytic organic reactions"

About the Seminar

Mechanistic study is presented as a central tool in the development of new, selective catalytic reactions. Two case studies are discussed. The first study highlights the development of quinone-based catalysts for the aerobic dehydrogenation of N-heterocycles. Inspired by quinone cofactors found in amine oxidase enzymes, this work identifies a new, abiological mechanism for substrate oxidation that proves critical for good catalytic efficiency and broad reaction scope. The second study highlights an enantioselective unimolecular substitution (SN1) reaction for the construction of quaternary stereogenic centers. A dual catalyst system is identified which is capable of generating – and controlling – highly electrophilic tertiary cations as reactive intermediates. Detailed mechanistic analysis supports a stepwise, stereoablative substitution pathway.

 

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